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The Extracta “Pipeline”

Extracts, their fractions, and resulting pure compounds are natural candidates for the development of phytotherapics (herbal medicines) and ethical drugs.


Pipeline Extracta



EXTRACTA BANK OF CHEMICAL BIODIVERSITY
HPLC
A vast collection of extracts and their derivatives isolated from the rich biodiversity in Brazil. Extraction and Processing Centers are located in Rio de Janeiro (Atlantic Rain Forest samples) and Belém do Pará (Eastern Amazonian samples). The Bank, with over 30,000 plant-derived chemical samples, is the first commercial collection accredited by CGEN - Board of Management of Genetic Resources, Ministry of Environment.

The BANK supports our screening activities in discovery and development of new active principles. The technology can be applied to a wide range of industrial interests in Health, Agriculture, Environmental Management, Energy and Mining.


CREATING AND DEVELOPPING DISCRIMINATORY BIOASSAYS FOR HTS
HPLC
Choice of target and development of discriminating bioassays are critical initial points in HTS exercises. Assembling 96-well plates containg the library and the bioassays are a robot-dependent preliminary step to screening.


Triagem da Coleção Extracta




MÉDIUM-HIGH THROUGHPUT SCREENING IN RIO (24,000 operations/day)
Robotic management of fluids at high speed permits presentation of library to every bioassay. Reading of results permits “cherry picking” and robotic rearrangement of true hits for further screening and deconvolution.


DECONVOLUTION TO ISOLATE ACTIVE COMPOUND
Chromatographic techniques (column, thin layer and HPLC) are used to fractionate extracts that yielded positive hits. Each such fraction is tested against the discriminatory bioassays to ensure that a useful purified compound will come out at the end.

HPLC  HPLC

OTHER SERVICES

DEVELOPMENT OF PLANT EXTRACTS, including the botanical, biomedical and phytochemical characterization needed for registration of novel phytotherapics.

PROTOCOL STANDARDIZATION FOR EXTRACTION AND QUALITY CONTROL FOR NOVEL PLANT MEDICINES for clients that produce and commercialize natural products.

EXTRACTA neither produces nor sells plant extracts. As a Research Services Company it sells only Kwoledge and Technologies.